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KMID : 0861020230380050031
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Korea Journal of Herbology
2023 Volume.38 No. 5 p.31 ~ p.37
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Effects of Boehmeria platanifolia Extract on Muscle Amelioration in Dexamethasone-Induced Muscle Atrophy Mouse Model
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Kim Mi-Sun
Yuk Heung-Joo
Kim Dong-Seon
Sung Yoon-Young
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Abstract
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Objective : This study was conducted to investigate the muscle-improving and therapeutic effects of Boehmeria
platanifolia (BP) in a mouse model of dexamethasone-induced muscle atrophy.
Methods : Muscle atrophy was induced in C57BL/6 mice by intraperitoneal administration of dexamethasone for 12
days. BP extract was administered orally at doses of 100 ㎎/㎏ and 200 ㎎/㎏ for 19 days, starting 7 days before the
intraperitoneal administration of dexamethasone. Mice were weighed during the experimental period, and muscle
strength and muscle weight were measured at the end of the experiment. The gastrocnemius (GASTROC) muscles
of mice were isolated and the cross-sectional area (CSA) of the muscle fibers was measured after H&E staining.
Results : Dexamethasone-induced muscle atrophy mice had a decrease in body weight compared to normal mice,
and BP-administrated mice did not show significant change in body weight compared with a control group. Muscle
strength in mice with induced muscle atrophy was reduced compared to normal and significantly increased with BP
administration and positive control. In addition, the weight of the quadriceps (QUAD) muscle and fiber size of the
GASTROC muscle, which was reduced in sarcopenia-induced mice, was increased by BP.
Conclusion : BP extract increased muscle strength, muscle weight, and muscle fiber size in dexamethasone-induced
muscle atrophy mice. This suggests that the efficacy of BP extracts in improving muscle strength and preventing and
treating sarcopenia may be beneficial for the development of potential therapeutic or functional products.
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KEYWORD
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Muscle atrophy, Sarcopenia, Dexamethasone, Grip strength, Boehmeria platanifolia
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